The pain of acute gout is unbearable

Acute gout is an immune response induced by the rapid change in urate concentration in the joint cavity, which leads to the secretion of inflammatory factors after phagocytosis of urate microcrystals. Generally, the onset is rapid, the pain is unbearable, and the joints and surrounding tissues are affected by redness, swelling, warmth, pain and other symptoms.

At present, the first-line medication of acute gout is Colchicine, NSAID, and COX-2 inhibitor, but these drugs have many toxic and side effects. Due to the high frequency of acute gout in gout patients, long-term medication is required. The toxic and side effects of first-line medications such as colchicine often limit their use in the field of gout. Patients with acute gout would be eager for the emergence of new drugs with equivalent efficacy and low toxicity.